Non-heme manganese(<scp>ii</scp>) complex-catalysed oxidative cleavage of 1,2-diols <i>via</i> alcohol-assisted O₂ activation

Photoenhanced oxidative DNA cleavage with non-heme iron(II) complexes.

The DNA cleavage activity of iron(II) complexes of a series of monotopic pentadentate N,N-bis(2-pyridylmethyl)-N-bis(2-pyridyl)methylamine (N4Py)-derived ligands (1-5) was investigated under laser irradiation at 473, 400.8, and 355 nm in the absence of a reducing agent and compared to that under ambient lighting. A significant increase in activity was observed under laser irradiation, which is ...

Iridium catalysed synthesis of piperazines from diols.

A green and atom-economical method has been developed for the synthesis of piperazines by cyclocondensation of diols and amines in aqueous media in the presence of a catalytic amount of [Cp*IrCl2]2.

Catalytic oxidative cleavage of catechol by a non-heme iron(III) complex as a green route to dimethyl adipate.

The catalyst system prepared in situ from iron(III) salts, tris(2-pyridylmethyl)amine and a base readily catalyses the intradiol dioxygenation of pyrocatechol in methanol, to primarily afford the half-methyl ester of muconic acid. Dimethyl adipate is obtained by the subsequent, one-step catalytic hydrogenation/esterification, thus providing a green route to this important nylon precursor.

University of Groningen Photoenhanced Oxidative DNA Cleavage with Non-Heme Iron(II) Complexes

Oxidative cleavage of vicinal diols: IBX can do what Dess-Martin periodinane (DMP) can.

The fact that IBX exhibits reactivity akin to DMP is demonstrated from the results observed with strained and sterically hindered syn 1,2-diols, which undergo oxidative cleavage via a 12-I-5 spirobicyclic periodinane. The use of TFA, a protonating solvent, promotes the formation of the 12-I-5 intermediate for 1,2-diols of all types (sec,sec, sec,tert and tert,tert), leading to efficient oxidati...